EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Synthesis and characterization of azole isoflavone inhibitors of aromatase.


PMID 15911319

Abstract

The synthesis and biological evaluation of a series of 2-azole and 2-thioazole isoflavones as potential aromatase inhibitors are described. Differences in inhibitory activity of triazole and imidazole inhibitors are rationalized with density functional theory to expose a key difference in the electronic structure of these molecules. In addition, difference binding spectra of inhibitors to immunoaffinity-purified aromatase produces classical Type II spectra consistent with coordination of the nitrogen lone pair electrons to the aromatase P450 heme.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

A9657
DL-Aminoglutethimide
C13H16N2O2