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Bioorganic & medicinal chemistry letters

DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives.


PMID 15914003

Abstract

A series of Ge132 derivatives have shown enhanced antitumor activity. Previous studies suggest that DNA can be their primary target. Here we show direct evidence that two newly synthesized Ge132 derivatives can intercalate into DNA. Unexpected methyl substitution effect of the novel derivatives on DNA sequence selectivity and cytotoxicity was observed.

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396265
Bis(2-carboxyethylgermanium(IV) sesquioxide), 99%
C6H10Ge2O7