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Organic letters

Synthesis of a laterally branched polyamine from alpha-methylene-gamma-butyrolactone.


PMID 15957916

Abstract

[reaction: see text] A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.

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226416
α-Methylene-γ-butyrolactone, 97%
C5H6O2