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Bioorganic & medicinal chemistry letters

Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin.


PMID 16005213

Abstract

The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of bacterial and fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient fungal whole-cell assay.