EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol.


PMID 16154745

Abstract

Based on the known coumarin-based prodrug system, a new meptazinol (Z)-3-[2-(propionyloxy) phenyl]-2-propenoic ester (3) was designed and synthesized as prodrug to minimize the first-pass effect of meptazinol (1) and improve the oral bioavailability. The prodrug (3) showed a 4-fold increase in oral bioavailability over the parent drug meptazinol in rats.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M2824
Meptazinol hydrochloride
C15H23NO· HCl