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Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.


PMID 16178579

Abstract

[reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions.

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287059
L-Prolinamide, 98%
C5H10N2O