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Nucleosides, nucleotides & nucleic acids

Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment.


PMID 16248081

Abstract

An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disulfide linkage with TCEP. The olgonucleotide was obtained without any basic treatment.