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Inflammopharmacology

Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.


PMID 16259714

Abstract

Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2alpha produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.

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F8549
Fluprostenol, 10 mg/mL in ethanol, 98%
C23H29F3O6