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Nucleosides, nucleotides & nucleic acids

New trends in synthesis of pyrazole nucleosides as new antimetabolites.


PMID 16270665

Abstract

Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.

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P56607
Pyrazole, 98%
C3H4N2