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Bioorganic & medicinal chemistry letters

Piperazinyl oxime ethers as NK-1 receptor antagonists.


PMID 16289817

Abstract

The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.

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G114
GR 73632, >97%
C40H59N7O6S