EMAIL THIS PAGE TO A FRIEND

Molecular diversity

Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison.


PMID 16311812

Abstract

Reactions using fluorous reagents and scavengers are compared side-by-side with their solid-supported counterparts. Fluorous triphenylphosphine is used in the bromination reaction of alcohols, fluorous thiol is used as an electrophile scavenger for alpha-bromoketones, fluorous isatoic anhydride is used as a nucleophile scavenger for primary and secondary amines. Reactions involving fluorous reagents and scavengers occur in homogeneous media with solution-phase reaction kinetics. Reactions with solid-supported reagents and scavengers occur in a heterogeneous media, and the reaction kinetics are greatly affected by the nature of the solid-support and reaction environment. Significantly larger amounts of reagents and more time are usually required to complete the solid-supported reaction.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

I12808
Isatoic anhydride, 96%
C8H5NO3