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Nature reviews. Cancer

KLF4, p21 and context-dependent opposing forces in cancer.


PMID 16372018

Abstract

Krüppel-like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell-cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?

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AV35721
Anti-KLF4 antibody produced in rabbit, IgG fraction of antiserum