EMAIL THIS PAGE TO A FRIEND

Biotechnology progress

Beta-galactosidase catalyzed selective galactosylation of aromatic compounds.


PMID 16454527

Abstract

A new approach to galacto-oligosaccharides and galacto-conjugates synthesis performed by the beta-galactosidase from Kluyveromyces lactis is reported. The enzymatic galactosylation of eight kinds of adsorbed aromatic primary alcohols, in particular the two drugs guaifenesin and chlorphenesin, gave the corresponding beta-D-galacto-pyranosides in yields ranging between approximately 10% and 96%. For the first time, we have showed that the adsorption of acceptor substrates onto solid supports such as silica gel influences the yield and the selectivity of galacto-conjugates synthesis. In particular, we observed that adsorption of acceptor favored the synthesis of digalactosylated compounds.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

191396
3-Aminobenzyl alcohol, 97%
C7H9NO