EMAIL THIS PAGE TO A FRIEND

British journal of cancer

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE.


PMID 16508633

Abstract

In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades.