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Bioorganic & medicinal chemistry letters

Small-molecule microarrays: development of novel linkers and an efficient detection method for bound proteins.


PMID 16682190

Abstract

Novel isocyanate and diazoketone linkers possessing polyoxypropylenediamine as a spacer for small-molecule microrray are developed. White light interferometry is introduced to detect bound proteins on the glass slides without using chemically modified proteins.

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