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Bioorganic & medicinal chemistry

New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.


PMID 16690318

Abstract

Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.

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D48400
2,6-Di-tert-butylphenol, 99%
C14H22O