EMAIL THIS PAGE TO A FRIEND

Clinical immunology (Orlando, Fla.)

T cell recognition in chronic beryllium disease.


PMID 16697706

Abstract

Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium exposure in the workplace and is characterized by the accumulation of beryllium-specific CD4(+) T cells. Depending on genetic susceptibility and the nature of the exposure, CBD occurs in up to 20% of exposed workers. Genetic susceptibility has been associated with particular HLA-DP alleles, especially those possessing a negatively charged glutamic acid residue at the 69th position of the beta-chain. The mechanism for this association lies in the ability of these HLA-DP molecules to bind and present beryllium to pathogenic CD4(+) T cells. Large numbers of effector memory, beryllium-specific CD4(+) T cells are recruited to the lung of these subjects and secrete Th1-type cytokines upon beryllium recognition. The presence of circulating beryllium-specific CD4(+) T cells directly correlates with the severity of lymphocytic alveolitis. With the presence of a known antigenic stimulus, CBD serves as an important model of immune-mediated, organ destruction. Thus, our findings in CBD have important implications for studies in autoimmune diseases, in particular those with an unknown inciting antigen and an inaccessible target organ.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

GF12366660
Beryllium, rod, 100mm, diameter 7.0mm, 99%
Be
GF41430787
Beryllium, wire reel, 0.05m, diameter 0.85mm, annealed and clean, 99%
Be
GF53985370
Beryllium, wire reel, 0.1m, diameter 0.75mm, annealed and clean, 99%
Be
GF46045627
Beryllium, wire reel, 0.2m, diameter 0.75mm, annealed and clean, 99%
Be
GF95797692
Beryllium, wire reel, 0.5m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF09275823
Beryllium, wire reel, 0.1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF73403142
Beryllium, wire reel, 0.1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF58877948
Beryllium, wire reel, 0.1m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF45831236
Beryllium, wire reel, 0.1m, diameter 0.5mm, annealed and clean, 99%
Be
GF96781214
Beryllium, wire reel, 0.1m, diameter 0.6mm, annealed and clean, 99%
Be
GF60949840
Beryllium, wire reel, 0.1m, diameter 0.85mm, annealed and clean, 99%
Be
GF59478586
Beryllium, wire reel, 0.2m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF75393388
Beryllium, wire reel, 0.2m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF59743738
Beryllium, wire reel, 0.2m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF29665086
Beryllium, wire reel, 0.2m, diameter 0.5mm, annealed and clean, 99%
Be
GF98865129
Beryllium, wire reel, 0.2m, diameter 0.6mm, annealed and clean, 99%
Be
GF79324959
Beryllium, wire reel, 0.2m, diameter 0.85mm, annealed and clean, 99%
Be
GF67966385
Beryllium, wire reel, 0.3m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF11051558
Beryllium, wire reel, 0.5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF34823224
Beryllium, wire reel, 0.5m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF24172703
Beryllium, wire reel, 0.5m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF81444764
Beryllium, wire reel, 1m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF52902840
Beryllium, wire reel, 1m, diameter 0.125mm, annealed and clean, 99.7%
Be
GF21588565
Beryllium, wire reel, 1m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF80595793
Beryllium, wire reel, 5m, diameter 0.05mm, annealed and clean, 99.7%
Be
GF02814702
Beryllium, mesh, 5x5mm, nominal aperture 0.13mm, thickness 0.025mm, wire diameter 0.1mm, 100 wires/inch, open area 50%, electro-formed mesh
Be
GF06987224
Beryllium, wire reel, 0.05m, diameter 0.25mm, annealed and clean, 99.7%
Be
GF21271025
Beryllium, wire reel, 0.05m, diameter 0.356mm, annealed and clean, 99.7%
Be
GF28341840
Beryllium, wire reel, 0.05m, diameter 0.5mm, annealed and clean, 99%
Be
GF65661363
Beryllium, wire reel, 0.05m, diameter 0.6mm, annealed and clean, 99%
Be