EMAIL THIS PAGE TO A FRIEND

Diabetes care

1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes.


PMID 16731998

Abstract

Postprandial hyperglycemia is often inadequately assessed in diabetes management. Serum 1,5-anhydroglucitol (1,5-AG) drops as serum glucose rises above the renal threshold for glucose and has been proposed as a marker for postprandial hyperglycemia. The objective of this study is to demonstrate the relationship between 1,5-AG and postprandial hyperglycemia, as assessed by the continuous glucose monitoring system (CGMS) in suboptimally controlled patients with diabetes. Patients with type 1 or type 2 diabetes and an HbA(1c) (A1C) between 6.5 and 8% with stable glycemic control were recruited from two sites. A CGMS monitor was worn for two consecutive 72-h periods. Mean glucose, mean postmeal maximum glucose (MPMG), and area under the curve for glucose above 180 mg/dl (AUC-180), were compared with 1,5-AG, fructosamine (FA), and A1C at baseline, day 4, and day 7. 1,5-AG varied considerably between patients (6.5 +/- 3.2 mug/ml [means +/- SD]) despite similar A1C (7.3 +/- 0.5%). Mean 1,5-AG (r = -0.45, P = 0.006) correlated with AUC-180 more robustly than A1C (r = 0.33, P = 0.057) or FA (r = 0.38, P = 0.88). MPMG correlated more strongly with 1,5-AG (r = -0.54, P = 0.004) than with A1C (r = 0.40, P = 0.03) or FA (r = 0.32, P = 0.07). 1,5-AG reflects glycemic excursions, often in the postprandial state, more robustly than A1C or FA. 1,5-AG may be useful as a complementary marker to A1C to assess glycemic control in moderately controlled patients with diabetes.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

54920
(R)-3-Hydroxybutyric acid, ≥98.0% (T)
C4H8O3
34867
1-Butanol, for HPLC, ≥99.7%
C4H10O
360465
1-Butanol, ACS reagent, ≥99.4%
C4H10O
33065
1-Butanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
C4H10O
537993
1-Butanol, 99.9%
C4H10O
901351
1-Butanol, ACS reagent, from renewable source, ≥99.4%
C4H10O
67520
1-Methyl-L-histidine, ≥98.0% (TLC)
C7H11N3O2
166898
3-Hydroxybutyric acid, 95%
C4H8O3
M9005
3-Methyl-L-histidine
C7H11N3O2
46204
4-Heptanone, analytical standard
C7H14O
W254606
4-Heptanone, ≥97%, FG
C7H14O
101745
4-Heptanone, 98%
C7H14O
270725
Acetone, for HPLC, ≥99.9%
C3H6O
34850
Acetone, for HPLC, ≥99.8%
C3H6O
179124
Acetone, ACS reagent, ≥99.5%
C3H6O
320110
Acetone, ACS reagent, ≥99.5%
C3H6O
673781
Acetone, ACS reagent, ≥99.5%
C3H6O
534064
Acetone, histological grade, ≥99.5%
C3H6O
32201
Acetone, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
C3H6O
24201
Acetone, puriss., meets analytical specification of Ph. Eur., BP, NF, ≥99% (GC)
C3H6O
179973
Acetone, Laboratory Reagent, ≥99.5%
C3H6O
L0625
D-(−)-Lactic acid, ≥90%
C3H6O3
295280
Dimethylamine, anhydrous, ≥99%
C2H7N
388246
Dimethylamine solution, 2.0 M in methanol
C2H7N
391956
Dimethylamine solution, 2.0 M in THF
C2H7N
426458
Dimethylamine solution, 40 wt. % in H2O
C2H7N
D1009
Dodecanedioic acid, 99%
C12H22O4
46565
Estriol, VETRANAL, analytical standard
C18H24O3
E-074
Estriol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
C18H24O3
67028
Methylglyoxal solution, technical, ~40% in H2O
C3H4O2