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Bioscience, biotechnology, and biochemistry

Properties of a trifluoroleucine-resistant mutant of Saccharomyces cerevisiae.


PMID 16861814

Abstract

We characterized a trifluoroleucine-resistant mutant of Saccharomyces cerevisiae, TFL20, that has a mutation in the LEU4 gene. We monitored the concentration of extracellular i-AmOH and intracellular amino acids, and compared the ratios of gene expression in TFL20 with the wild-type strain, K30. We found that the LEU1, LEU2, and BAT1 genes were up-regulated in TFL20 for metabolism, and that TFL20 simultaneously produced as much i-AmOH and leucine as K30 does.

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91917
5,5,5-Trifluoro-DL-leucine, ≥98.0% (sum of isomers, HPLC)
C6H10F3NO2