EMAIL THIS PAGE TO A FRIEND

Journal of cardiovascular pharmacology

Dose-plasma concentration--effect relationship of felodipine in essential hypertension: a review.


PMID 1693728

Abstract

Calcium antagonists demonstrate a close relationship between plasma drug level and effect on blood pressure (BP). Thus, the intensity and duration of action can be influenced by dose and disposition. Felodipine has a dose-related effect on diastolic BP whether given alone or with a beta-blocker. The latter combination reduces adverse effects and improves tolerability, particularly at higher (20 mg/day) doses of felodipine. Felodipine 5 or 10 mg/day in an extended release formulation could be predicted to lower BP throughout a 24-h period. The results of formal prospective clinical trials confirm the predictions and indicate that felodipine can be used as a once-daily agent in essential hypertension.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

F9677
Felodipine, solid
C18H19NO4Cl2
F0030000
Felodipine, European Pharmacopoeia (EP) Reference Standard
C18H19NO4Cl2