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Bioorganic chemistry

Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.


PMID 16945403

Abstract

Several Toyocamycin (4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio (18) and 5-carboxamide oxime derivatives (23 and 27) of Toyocamycin were found to have good activity and selectivity.

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T3580
Toyocamycin, ≥98% (HPLC), from Streptomyces rimosus
C12H13N5O4