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Organic letters

Lithiation directed by amino alkoxides. Application to the synthesis of new disubstituted dihydrodipyridopyrazines.


PMID 16956183

Abstract

The synthesis of new 4,6-disubstituted dihydrodipyridopyrazines starting from corresponding carboxaldehydes via lithiation directed by alpha-amino alkoxides is described. The N,N,N'-trimethylethylenediamine was used as amine component for in situ formation of the alpha-amino alkoxides. After optimization, this reaction allowed easy access to new interesting starting materials for further applications by palladium-catalyzed reactions.

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127124
N,N,N′-Trimethylethylenediamine, 97%
C5H14N2