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Organic letters

An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore.


PMID 17192081

Abstract

[reaction: see text] A key structural feature of the Neocarzinostatin chromophore is a reactive epoxydiyne. We present here a new method for the preparation of epoxydiynes by the addition of an allenyl zinc bromide to a propargylic ketone.