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European journal of medicinal chemistry

Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents.


PMID 17346862

Abstract

The synthesis of 9- and 6-alkylaminomethyl furoflavones 5a, b, 9a-c, 13a, b, 15a-g and 18 from the naturally occurring chromones visnagin and khellin. Gastroprotective potency of these compounds in the ethanol damage model was determined. The results indicate that, through appropriate substitution, furoflavones can be obtained that are gastroprotective.

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