EMAIL THIS PAGE TO A FRIEND

Biophysical journal

Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin.


PMID 17483159

Abstract

Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and cinnamycin to PE-containing liposomes is dependent on membrane curvature, i.e., the lantibiotics bind small vesicles more efficiently than large liposomes. The binding of the lantibiotics to multilamellar liposomes induces tubulation of membranes, as revealed by electron microscopy and small-angle x-ray scattering. These results suggest that both duramycin and cinnamycin promote their binding to the PE-containing membrane by deforming membrane curvature.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D3168 Duramycin from Streptoverticillium cinnamoneus, ≥90.0%
C89H125N23O25S3