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Bioorganic & medicinal chemistry letters

Praziquantel derivatives I: Modification of the aromatic ring.


PMID 17555960

Abstract

Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.

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P4668
Praziquantel, anthelminic, neurogenic
C19H24N2O2