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Bioorganic & medicinal chemistry letters

The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.


PMID 17761416

Abstract

This communication highlights the development of a nicotinamide series of histone deacetylase inhibitors within the benzamide structural class. Extensive exploration around the nicotinamide core led to the discovery of a class I selective HDAC inhibitor that possesses excellent intrinsic and cell-based potency, acceptable ancillary pharmacology, favorable pharmacokinetics, sustained pharmacodynamics in vitro, and achieves in vivo efficacy in an HCT116 xenograft model.

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A68203
6-Aminonicotinamide, 99%
C6H7N3O