EMAIL THIS PAGE TO A FRIEND

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin.


PMID 1782616

Abstract

3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

N5636
3-Nitropropionic acid, ≥97%
C3H5NO4