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Bioorganic & medicinal chemistry letters

Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.


PMID 17981461

Abstract

The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.

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