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The Journal of organic chemistry

Chlorination/cyclodehydration of amino alcohols with SOCl2: an old reaction revisited.


PMID 18052293

Abstract

A simple, one-pot preparation of cyclic amines via efficient chlorination of amino alcohols with use of SOCl(2) has been developed. This approach obviates the need for the classical N-protection/O-activation/cyclization/deprotection sequence commonly employed for this type of transformation. The reaction pathways and the general scope of this method have also been investigated.