EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

Synthesis and biological evaluation of imidazol-2-one derivatives as potential antitumor agents.


PMID 18226907

Abstract

A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

456187
3,4,5-Trimethoxyphenyl isocyanate, 97%
C10H11NO4