EMAIL THIS PAGE TO A FRIEND

Journal of enzyme inhibition and medicinal chemistry

pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines.


PMID 18341247

Abstract

Several synthetic N-substituted N-nitrosohydroxylamines were found to inhibit mushroom tyrosinase in a pH-dependent manner regardless of the N-substituent. The inhibitory activity, or pI(50) ( - log [IC(50), M]) value, linearly decreased as the pH of the media increased. The inhibitory activities of tested N-substituted N-nitrosohydroxylamines at pH 6.8 and 5.8 were found to be almost 10 times and 100 times greater than at pH 7.8, respectively. The types of inhibition were different at pH 6.8 and 5.8. These results suggest that the inhibitory effect of N-substituted N-nitrosohydroxylamines is caused by the non-ionized form of the inhibitor. Furthermore, the mechanism of inhibition depends on the interaction between the inhibitor and the active site of tyrosinase at different pH values.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

412260
Benzhydroxamic acid, 99%
C7H7NO2