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Molecular diversity

Reaction of 5-aminotetrazole with vinamidinium salts: formation of 2-(N, N-dimethylamino)-5-substituted pyrimidines.


PMID 18365762

Abstract

The cyclocondensation of vinamidinium salts with 5-aminotetrazole in basic media affords regiospecifically good yields of 2-(N, N-dimethylamino)-5- aryl-, arylsulfonyl- and 2-(N, N-dimethylamino)-5-formyl-pyrimidines, respectively.