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Bioorganic & medicinal chemistry letters

Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides.


PMID 18595691

Abstract

Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.

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