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The Journal of antibiotics

Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.


PMID 18653995

Abstract

Total synthesis of a fungal cyclic peptide, malformin C, recently rediscovered as a G2 checkpoint inhibitor was completed. Our synthesis involved a convergent approach with respect to a linear pentapeptide, cyclization, and oxidative disulfide formation.