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Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

[Synthesis of diethyl N-[p-(methylamino)benzoyl]-L-glutamate].


PMID 18677396

Abstract

To find a best synthesis method of diethyl N-[p-(methylamino)benzoyl]-L-glutamate(1). Using diethyl N-(p- aminobenzoyl)-L-glutamate (2) as a starting material via a one-pot process of benzylation and methylation, the diethyl N-[p-(methylamino)benzoyl ]-L-glutamate (3) is prepared in high yield. Then compound 1 was conveniently obtained from debenzylation of compound 3 by Pd/C. The target compound was obtained through 2-step reaction in 88% overall yield in only 6 h, and its structure was identified by 1HNMR and MS. It is a convenient and efficient method of preparation of diethyl N-[p-(methylamino)benzoyl]-L-glutamate.

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