EMAIL THIS PAGE TO A FRIEND

Chirality

Application of kinetic resolution using HCS as chiral auxiliary: novel synthesis of beta-blockers (S)-betaxolol and (S)-metoprolol.


PMID 18988258

Abstract

Optically pure (S)-betaxolol and (S)-metoprolol were prepared with an extremely facile and practical method using kinetic resolution of beta-amino alcohols employing HCS as chiral auxiliary. High enantiomeric purity (ee > 99%) was achieved and the synthetic strategy is amenable to industrial scale-up.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

B5683
Betaxolol hydrochloride, >98% (HPLC)
C18H29NO3 · HCl