EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Synthesis and biological evaluation of a series of tangeretin-derived chalcones.


PMID 19013795

Abstract

A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2'-hydroxy-3',4',5',6'-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, activation of apoptosis, inhibition of tubulin assembly and antileishmanial activities. Comparison with the reference analogous 3',4',5'-trimethoxylated chalcones showed that such peroxygenated substitution patterns on the ring A were less beneficial to these activities.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

T8951
Tangeretin, ≥95% (HPLC)
C20H20O7