EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-inflammatory agents.


PMID 19038546

Abstract

To improve the medicinal activity, the structure of diflunisal has been modified. Twenty-one amide derivatives of diflunisal were synthesized starting from diflunisal in three steps with total yields from 72% to 89%. All compounds were identified by (1)H NMR, MS, and elemental analysis. The anti-inflammatory and analgesic activities for 19 compounds were evaluated. It was found that 5m possesses an excellent anti-inflammatory activity and a good analgesic activity, maybe a potential anti-inflammatory agent.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D3281
Diflunisal, analytical standard
C13H8F2O3