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Antonie van Leeuwenhoek

Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica.


PMID 19125348

Abstract

Strain AM105 was separated from mangrove sediment in the South China Sea in this research. The morphological and genomic data showed that the strain merits description as a novel species, proposed as Micromonospora rifamycinica. From the acetate ethyl extract of its fermentation broth, two antibiotics against Gram-positive bacteria (including MRSA), rifamycin S and its geometric isomer were isolated. Their structures were elucidated on the basis of spectroscopic analyzes. (1)H and (13)C NMR data of the isomer of rifamycin S were first described in this paper.

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R0950000 Rifamycin S, European Pharmacopoeia (EP) Reference Standard
C37H45NO12