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Bioresource technology

A novel medium for the production of cephamycin C by Nocardia lactamdurans using solid-state fermentation.


PMID 19155173

Abstract

In this study, Nocardia lactamdurans NRRL 3802 was explored for the first time for production of cephamycin C by using solid-state fermentation. The effects of various substrates, moisture content, inoculum size, initial pH of culture medium, additional nitrogen source and amino acids were investigated for the maximum production of cephamycin C by N. lactamdurans NRRL 3802 in solid-state fermentation. Subsequently, selected fermentation parameters were further optimized by response surface methodology (RSM). The soybean flour as a substrate with moisture content of 65%, initial pH of culture medium of 6.5 and inoculum size of 10(9)CFU/ml (2 x 10(8)CFU/gds) at 28+/-2 degrees C after 4 days gave maximum production of 15.75+/-0.27 mg/gds of cephamycin C as compared to 8.37+/-0.23 mg/gds before optimization. Effect of 1,3-diaminopropane on cephamycin C production was further studied, which further increased the yield to 27.64+/-0.33 mg/gds.

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D23807
1,3-Diaminopropane dihydrochloride, 98%
C3H10N2 · 2HCl