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Bioorganic & medicinal chemistry letters

A novel class of allosteric modulators of AMPA/Kainate receptors.


PMID 19162477

Abstract

The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.

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I5773
IDRA 21, ≥98%
C8H9ClN2O2S