EMAIL THIS PAGE TO A FRIEND

Journal of the American Chemical Society

Magnesium-catalyzed asymmetric direct aldol addition of ethyl diazoacetate to aromatic, aliphatic, and alpha,beta-unsaturated aldehydes.


PMID 19191696

Abstract

Magnesium-catalyzed enantioselective aldol between ethyl diazoacetate and aromatic, aliphatic, and alpha,beta-unsaturated aldehydes affords alpha-diazo-beta-hydroxy-esters in high enantioselectivities. Aldol adducts resulting from this asymmetric transformation are versatile intermediates toward the synthesis of several ester containing chiral building blocks.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

E22201
Ethyl diazoacetate, contains ≥13 wt. % dichloromethane
C4H6N2O2