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Bioorganic & medicinal chemistry letters

Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.


PMID 19289282

Abstract

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.