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Bioorganic & medicinal chemistry letters

GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.


PMID 19307116

Abstract

5-Alkyl and aryl-pyrazole-tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.

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524697
2,3,5-Trifluorophenylboronic acid, ≥95%
C6H4BF3O2