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Journal of the American Chemical Society

Palladium-catalyzed intramolecular direct arylation of benzoic acids by tandem decarboxylation/C-H activation.


PMID 19317495

Abstract

A novel protocol for the palladium-catalyzed intramolecular direct arylation of benzoic acids is reported, which combines decarboxylation and C-H activation into one efficient process. With the optimized catalyst system of palladium trifluoroacetate, silver carbonate, and the proper solvent mixture (5% DMSO/dioxane), dibenzofuran derivatives are formed in excellent yield and selectivity.