EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.


PMID 19414254

Abstract

We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

E7881
Emodin, from Frangula bark, ≥90% (HPLC)
C15H10O5