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Bioorganic & medicinal chemistry letters

Semisynthesis and pharmacological activities of Tetrac analogs: angiogenesis modulators.


PMID 19427201

Abstract

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.

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T3787
3,3′,5,5′-Tetraiodothyroacetic acid
C14H8I4O4