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Reduced NGF secretion by HT-29 human colon cancer cells treated with a GRPR antagonist.


PMID 19519524

Abstract

The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human colon carcinoma cells. The results suggest that decreased secretion of neurotrophins might be a novel mechanism by which GRPR antagonists exert their antiproliferative effects in cancer cells.

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R9653
RC-3095, ≥95% (HPLC), lyophilized powder
C56H79N15O9 · xC2HF3O2