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American journal of clinical oncology

Phase II study of aminothiadiazole in advanced squamous cell carcinoma of the esophagus.


PMID 1987735

Abstract

Twenty-three patients with advanced inoperable squamous cell carcinoma of the esophagus were treated with aminothiadiazole (A-TD) 125 mg/m2 weekly plus allopurinol daily in a phase II cooperative group trial. No patients responded to treatment; 17 patients progressed, three showed stable disease, and three were unevaluable. There were no life-threatening hematologic or metabolic toxicities. The median survival from study entry was 5 months. A-TD is not active in advanced squamous cell carcinoma of the esophagus.

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258881
2-Amino-1,3,4-thiadiazole, 97%
C2H3N3S